解剖学和形态学
麻醉学
听力与言语-语言病理学
行为科学
心脏和心血管系统
细胞和组织工程学
临床神经病学
危重症监护医学
牙科,口腔外科和医学
皮肤病学
急诊医学
内分泌学和新陈代谢
肠胃学和肝脏学
老人病学和老年医学
卫生保健科学和服务
血液学
免疫学
传染病
综合和补充性医学
医学伦理学
医学信息学
医学实验室技术
医学,全科和内科
医学,法律
医学,研究和试验
神经系统科学
护理
营养学和饮食学
产科医学和妇科医学
肿瘤学
眼科学
整形外科学
耳鼻喉科学
病理学
儿科学
周围血管疾病
药理学和药剂学
生理学
基本医疗保健
精神病学
公共、环境和职业卫生
放射学,核医学和医学成像
康复学
生殖生物学
呼吸系统
风湿病学
运动科学
外科学
毒理学
热带医学
泌尿学和肾脏学
病毒学
老年医学
健康政策和服务
心理学,临床
abstract:BACKGROUND:Pathogen perception by plants is mediated by plasma membrane-localized immune receptors that have varied extracellular domains. Lectin receptor kinases (LecRKs) are among these receptors and are subdivided into 3 classes, C-type LecRKs (C-LecRKs), L-type LecRKs (L-LecRKs) and G-type LecRKs (G-LecRKs). While ...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/s12864-018-4606-0
更新日期:2018-04-06 00:00:00
abstract:BACKGROUND:Aggression is influenced by individual variation in temperament as well as behavioral plasticity in response to adversity. DNA methylation is stably maintained over time, but also reversible in response to specific environmental conditions, and may thus be a neuromolecular regulator of both of these processe...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/s12864-018-4594-0
更新日期:2018-03-26 00:00:00
abstract:BACKGROUND:Understanding the diversity of repair outcomes after introducing a genomic cut is essential for realizing the therapeutic potential of genomic editing technologies. Targeted PCR amplification combined with Next Generation Sequencing (NGS) or enzymatic digestion, while broadly used in the genome editing field...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/s12864-018-4561-9
更新日期:2018-03-21 00:00:00
abstract:BACKGROUND:Human herpesvirus-6A and -6B (HHV-6) are betaherpesviruses that reach > 90% seroprevalence in the adult population. Unique among human herpesviruses, HHV-6 can integrate into the subtelomeric regions of human chromosomes; when this occurs in germ line cells it causes a condition called inherited chromosomall...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/s12864-018-4604-2
更新日期:2018-03-20 00:00:00
abstract:BACKGROUND:Bulbs of the ornamental flower Lilium pumilum enter a period of dormancy after flowering in spring, and require exposure to cold for a period of time in order to release dormancy. Previous studies focused mainly on anatomical, physiological and biochemical changes during dormancy release. There are no dorman...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/s12864-018-4536-x
更新日期:2018-03-14 00:00:00
abstract:BACKGROUND:Cryptocaryon irritans is an obligate parasitic ciliate protozoan that can infect various commercially important mariculture fish species and cause high lethality and economic loss. Current methods of controlling this parasite with chemicals or antibiotics are widely considered to be environmentally harmful. ...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/s12864-018-4565-5
更新日期:2018-03-12 00:00:00
abstract:BACKGROUND:Aspergillus arachidicola is an aflatoxigenic fungal species, first isolated from the leaves of a wild peanut species native to Argentina. It has since been reported in maize, Brazil nut and human sputum samples. This aflatoxigenic species is capable of secreting both B and G aflatoxins, similar to A. parasit...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/s12864-018-4576-2
更新日期:2018-03-09 00:00:00
abstract:BACKGROUND:The ballan wrasse (Labrus bergylta) belongs to a large teleost family containing more than 600 species showing several unique evolutionary traits such as lack of stomach and hermaphroditism. Agastric fish are found throughout the teleost phylogeny, in quite diverse and unrelated lineages, indicating stomach ...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/s12864-018-4570-8
更新日期:2018-03-06 00:00:00
abstract:BACKGROUND:Obtaining complete gene structures is one major goal of genome assembly. Some gene regions are fragmented in low quality and high-quality assemblies. Therefore, new approaches are needed to recover gene regions. Genomes are widely transcribed, generating messenger and non-coding RNAs. These widespread transc...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/s12864-018-4567-3
更新日期:2018-03-02 00:00:00
abstract:BACKGROUND:ATAC-seq (Assays for Transposase-Accessible Chromatin using sequencing) is a recently developed technique for genome-wide analysis of chromatin accessibility. Compared to earlier methods for assaying chromatin accessibility, ATAC-seq is faster and easier to perform, does not require cross-linking, has higher...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/s12864-018-4559-3
更新日期:2018-03-01 00:00:00
abstract:BACKGROUND:Despite recent work to characterize gene expression changes associated with larval development in oysters, the mechanism by which the larval shell is first formed is still largely unknown. In Crassostrea gigas, this shell forms within the first 24 h post fertilization, and it has been demonstrated that chang...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/s12864-018-4519-y
更新日期:2018-02-22 00:00:00
abstract:BACKGROUND:Current technologies in next-generation sequencing are offering high throughput reads at low costs, but still suffer from various sequencing errors. Although pyro- and ion semiconductor sequencing both have the advantage of delivering long and high quality reads, problems might occur when sequencing homopoly...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/s12864-018-4544-x
更新日期:2018-02-21 00:00:00
abstract:BACKGROUND:Atlantic salmon production in Tasmania (Southern Australia) occurs near the upper limits of the species thermal tolerance. Summer water temperatures can average over 19 °C over several weeks and have negative effects on performance and health. Liver tissue exerts important metabolic functions in thermal adap...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/s12864-018-4517-0
更新日期:2018-02-12 00:00:00
abstract:BACKGROUND:Gibberella ear rot (GER) is one of the most economically important fungal diseases of maize in the temperate zone due to moldy grain contaminated with health threatening mycotoxins. To develop resistant genotypes and control the disease, understanding the host-pathogen interaction is essential. RESULTS:RNA-...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/s12864-018-4513-4
更新日期:2018-02-09 00:00:00
abstract:BACKGROUND:Polypyrimidine-tract binding proteins (PTBs) are ubiquitous RNA-binding proteins in plants and animals that play diverse role in RNA metabolic processes. PTB proteins bind to target RNAs through motifs rich in cytosine/uracil residues to fine-tune transcript metabolism. Among tuber and root crops, potato has...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/s12864-018-4502-7
更新日期:2018-02-07 00:00:00
abstract:BACKGROUND:Transposable elements (TEs) are mobile genetic sequences that randomly propagate within their host's genome. This mobility has the potential to affect gene transcription and cause disease. However, TEs are technically challenging to identify, which complicates efforts to assess the impact of TE insertions on...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/s12864-018-4485-4
更新日期:2018-02-01 00:00:00
abstract:BACKGROUND:Rhizobial symbionts belong to the classes Alphaproteobacteria and Betaproteobacteria (called "alpha" and "beta"-rhizobia). Most knowledge on the genetic basis of symbiosis is based on model strains belonging to alpha-rhizobia. Mimosa pudica is a legume that offers an excellent opportunity to study the adapta...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/s12864-018-4487-2
更新日期:2018-01-30 00:00:00
abstract:BACKGROUND:Runs of Homozygosity (ROH) are genomic regions where identical haplotypes are inherited from each parent. Since their first detection due to technological advances in the late 1990s, ROHs have been shedding light on human population history and deciphering the genetic basis of monogenic and complex traits an...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/s12864-018-4489-0
更新日期:2018-01-30 00:00:00
abstract:BACKGROUND:Emerging evidence has been experimentally confirmed the tissue-specific expression of circRNAs (circRNAs). Global identification of human tissue-specific circRNAs is crucial for the functionality study, which facilitates the discovery of circRNAs for potential diagnostic biomarkers. RESULTS:In this study, c...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/s12864-017-4335-9
更新日期:2018-01-19 00:00:00
abstract:BACKGROUND:RNA editing is an important mechanism that expands the diversity and complexity of genetic codes. The conversions of adenosine (A) to inosine (I) and cytosine (C) to uridine (U) are two prominent types of RNA editing in animals. The roles of RNA editing events have been implicated in important biological pat...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/s12864-017-4330-1
更新日期:2018-01-19 00:00:00
abstract:BACKGROUND:Papain-like cysteine proteases (PLCPs), a large group of cysteine proteases structurally related to papain, play important roles in plant development, senescence, and defense responses. Papain, the first cysteine protease whose structure was determined by X-ray crystallography, plays a crucial role in protec...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/s12864-017-4394-y
更新日期:2018-01-06 00:00:00
abstract:BACKGROUND:Due to the predominant usage of short-read sequencing to date, most bacterial genome sequences reported in the last years remain at the draft level. This precludes certain types of analyses, such as the in-depth analysis of genome plasticity. RESULTS:Here we report the finalized genome sequence of the envir...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/s12864-017-4301-6
更新日期:2018-01-05 00:00:00
abstract:BACKGROUND:Molecular mechanisms underlying coral larval competence, the ability of larvae to respond to settlement cues, determine their dispersal potential and are potential targets of natural selection. Here, we profiled competence, fluorescence and genome-wide gene expression in embryos and larvae of the reef-buildi...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/s12864-017-4392-0
更新日期:2018-01-04 00:00:00
abstract:BACKGROUND:The unisexual Amazon molly (Poecilia formosa) originated from a hybridization between two sexual species, the sailfin molly (Poecilia latipinna) and the Atlantic molly (Poecilia mexicana). The Amazon molly reproduces clonally via sperm-dependent parthenogenesis (gynogenesis), in which the sperm of closely re...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/s12864-017-4382-2
更新日期:2018-01-03 00:00:00
abstract:BACKGROUND:Lipopolysaccharide (LPS) from Gram-negative bacteria cause innate immune responses in animals and plants. The molecules involved in LPS signaling in animals are well studied, whereas those in plants are not yet as well documented. Recently, we identified Arabidopsis AtLBR-2, which binds to LPS from Pseudomon...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/s12864-017-4372-4
更新日期:2017-12-29 00:00:00
abstract:BACKGROUND:Synthetic systems that use positive feedback have been developed to control human disease vectors and crop pests. The tTAV system, which has been deployed in several insect species, relies on a positive feedback circuit that can be inhibited via dietary tetracycline. Although insects carrying tTAV fail to su...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/s12864-017-4385-z
更新日期:2017-12-28 00:00:00
abstract:BACKGROUND:Lactose provides an easily-digested energy source for neonates, and is the primary carbohydrate in milk in most species. Bovine lactose is also a key component of many human food products. However, compared to analyses of other milk components, the genetic control of lactose has been little studied. Here we ...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/s12864-017-4320-3
更新日期:2017-12-15 00:00:00
abstract:BACKGROUND:Drought is a lifestyle disease. Plant metabolomics has been exercised for understanding the fine-tuning of the potential pathways to surmount the adverse effects of drought stress. A broad spectrum of morphological and metabolic responses from seven Triticeae species including wild types with different droug...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/s12864-017-4321-2
更新日期:2017-12-15 00:00:00
abstract:BACKGROUND:DNA methylation at promoters is largely correlated with inhibition of gene expression. However, the role of DNA methylation at enhancers is not fully understood, although a crosstalk with chromatin marks is expected. Actually, there exist contradictory reports about positive and negative correlations between...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/s12864-017-4353-7
更新日期:2017-12-12 00:00:00
abstract:BACKGROUND:Identification of acute or recent hepatitis C virus (HCV) infections is important for detecting outbreaks and devising timely public health interventions for interruption of transmission. Epidemiological investigations and chemistry-based laboratory tests are 2 main approaches that are available for identifi...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/s12864-017-4269-2
更新日期:2017-12-06 00:00:00
abstract:BACKGROUND:Skin and its mucus are known to be the first barrier of defence against any external stressors. In fish, skin wounds frequently appear as a result of intensive culture and also some diseases have skin ulcers as external clinical signs. However, there is no information about the changes produced by the wounds...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/s12864-017-4349-3
更新日期:2017-12-02 00:00:00
abstract:BACKGROUND:Aneuploidies are copy number variants that affect entire chromosomes. They are seen commonly in cancer, embryonic stem cells, human embryos, and in various trisomic diseases. Aneuploidies frequently affect only a subset of cells in a sample; this is known as "mosaic" aneuploidy. A cell that harbours an aneup...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/s12864-017-4253-x
更新日期:2017-11-25 00:00:00
abstract:BACKGROUND:Aging is associated with functional decline of neurons and increased incidence of both neurodegenerative and ocular disease. Photoreceptor neurons in Drosophila melanogaster provide a powerful model for studying the molecular changes involved in functional senescence of neurons since decreased visual behavio...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/s12864-017-4304-3
更新日期:2017-11-21 00:00:00
abstract:BACKGROUND:Cardiorespiratory fitness (VO2max) is an excellent predictor of chronic disease morbidity and mortality risk. Guidelines recommend individuals undertake exercise training to improve VO2max for chronic disease reduction. However, there are large inter-individual differences between exercise training responses...
journal_title:BMC genomics
pub_type: 杂志文章,评审
doi:10.1186/s12864-017-4192-6
更新日期:2017-11-14 00:00:00
abstract:BACKGROUND:Cotton (Gossypium spp.) is commonly grouped into eight diploid genomic groups and an allotetraploid genomic group, AD. The mitochondrial genomes supply new information to understand both the evolution process and the mechanism of cytoplasmic male sterility. Based on previously released mitochondrial genomes ...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/s12864-017-4282-5
更新日期:2017-11-13 00:00:00
abstract:BACKGROUND:Sclerotinia Stem Rot (SSR), caused by the fungal pathogen Sclerotinia sclerotiorum, is ubiquitous in cooler climates where soybean crops are grown. Breeding for resistance to SSR remains challenging in crops like soybean, where no single gene provides strong resistance, but instead, multiple genes work toget...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/s12864-017-4160-1
更新日期:2017-11-07 00:00:00
abstract:BACKGROUND:Complete mitochondrial genomes are much better suited for the taxonomic identification and phylogenetic studies of nematodes than morphology or traditionally-used molecular markers, but they remain unavailable for the entire Camallanidae family (Chromadorea). As the only published mitogenome in the Camallani...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/s12864-017-4237-x
更新日期:2017-11-02 00:00:00
abstract:BACKGROUND:Typhoid fever is an acute systemic infection of humans caused by Salmonella enterica subspecies enterica serovar Typhi (S. Typhi). In chronic carriers, the bacteria survive the harsh environment of the gallbladder by producing biofilm. The phenotype of S. Typhi biofilm cells is significantly different from t...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/s12864-017-4212-6
更新日期:2017-10-31 00:00:00
abstract:BACKGROUND:Ocean acidification (OA), a change in ocean chemistry due to the absorption of atmospheric CO2 into surface oceans, challenges biogenic calcification in many marine organisms. Ocean acidification is expected to rapidly progress in polar seas, with regions of the Southern Ocean expected to experience severe O...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/s12864-017-4161-0
更新日期:2017-10-23 00:00:00
abstract:BACKGROUND:Molecular characterization is important for efficient utilization of germplasm and development of improved varieties. In the present study, we investigated the genetic purity, relatedness and population structure of 265 maize inbred lines from the Ethiopian Institute of Agricultural Research (EIAR), the Inte...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/s12864-017-4173-9
更新日期:2017-10-12 00:00:00